Methylation, Health & Disease – Why Is It Important Webinar [RECORDING]


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Title: Methylation, Health and Disease – Why Is It Important

Presenter: Dr Elisabeth Philipps PhD BSc (Hons) BSc Nutr Med

You might have read this webinar title and thought “What is methylation and why should I care about it?” The answer is simple – when the methylation cycle is functioning optimally, this biochemical process that occurs billions of times every second throughout our body has significant positive impact in many systems, including supporting energy production, heart health, brain function and mood and detoxification. In fact, poor methylation has been linked to many health conditions including Alzheimer’s disease[1], Polycystic Ovary Syndrome (PCOS)[2], Multiple Sclerosis (MS)[3], depression[4], migraines[5] and heart disease.[6] It’s also a process that is increased during times of stress so arguably methylation support should be a crucial part of most people’s lives.

Methylation is reliant on number of key nutrients, which is why the diet plays such a crucial role in this cycle. Folate, a B vitamin, is critical for methylation cycle but is form dependent. Folic acid found in many food supplements and food sources of folate are not biologically active and need to be converted to the metabolically active form of methylfolate (5-MTHF) in the body. Some individuals, due to their unique genetic patterns and expression (i.e. polymorphisms), do not produce adequate or effective folate converting enzymes. In fact, certain common mutations in this gene can reduce our ability to produce active methylfolate by up to 70%, which negatively impacts the methylation cycle function.

Elisabeth will provide an up to date summary of current approaches to successfully managing the methylation cycle through nutritional interventions and carefully selected supplements.

Webinar topics covered include:

  • The latest research into the role of the methylation cycle, health and disease.
  • Testing for folate enzyme mutations.
  • Comparing and contrasting different forms of supplementary folate and Vitamin B12 to support rather than hinder the methylation process.
  • Clinical application of relevant supplements to support methylation including Vitamin B12, magnesium, Vitamin B6, betaine and choline.
  • Dietary interventions and environmental and lifestyle support to optimise the methylation cycle.

This comprehensive webinar will provide you with a complete and effective framework for managing methylation with practical information on successful functional nutrition programmes. A full set of scientifically referenced slides and recording of the webinar are included in the investment price.


  1. McCaddon A. Vitamin B12 in neurology and ageing; clinical and genetic aspects. Biochimie. 2013; 95(5):1066-1076.
  2. Wang XX et al. Genome-wide DNA methylation and gene expression patterns provide insight into polycystic ovary syndrome development. Oncotarget. 2014;5(16):6603-661
  3. Neven KY et al. Repetitive element hypermethylation in multiple sclerosis patients. BMC Genet. 2016;17(1):84
  4. Gandolfo G et al. Association of the COMT synonymous polymorphism Leu136Leu and missense variant Vak158Met with mood disorders. J Affect Disord. 2015; 177:108-113
  5. Liu A et al. Analysis of the MTHFR C677T variant with migraine phenotypes. . BMC Research Notes 2010;3:213.
  6. Wernimont SM et al. Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans. J Nutr.2011;141(2):255-60